Title: High rates of mineralocorticoid receptor antagonist discontinuation in patients with hypertension: Insights from the enlighten study

Objective: Mineralocorticoid receptor antagonists (MRAs) are indicated for several cardiovascular (CV) conditions, including heart failure (HF) and hypertension (HTN). However, adverse drug reactions or dose-limiting side-effects may lead to discontinuation. We aimed to descri [....] » Read More

Title: Diabetic cardiomyopathy and metal-mediated inflammation and cell deaths

Cardiac inflammation and myocyte death are essential for initiating the pathogenesis and progression of various etiological cardiomyopathies, including diabetic cardiomyopathy (DCM), reported in 1972. Cardiac cell death was detected in the hearts of patients with diabetes and ani [....] » Read More

Title: Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel function in the atrium from patients with atrial fibrillation

Background: Atrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (Khib) in AF is still unknown. This s [....] » Read More

Title: Principles and standards for designing and managing integration and interoperability of intelligent and ethical transformed health ecosystems

Health and social care systems around the world undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions in personal, social, occupational, [....] » Read More

Title: Multifunctional nanosystems for precision diagnosis and detoxification in cardiovascular diseases: From multimodal imaging of myocarditis to cardioprotective chemotherapy

Background and Objective: Early diagnosis and cardioprotection remain key challenges in the management of inflammatory and chemotherapy-induced cardiac injuries. To address these, our research team has developed macrophage membrane-modified nanoparticles (MM/NPs) to guide early n [....] » Read More

Title: Arterial and venous grafting biomaterials in coronary surgery: Integrative multi-omics approach reveals ECM-PI3K-Akt pathway as key regulator of different patency

Background: Biomaterials used as grafts in coronary artery bypass grafting (CABG) surgery are autologous arteries (internal mammary artery [IMA] and radial artery [RA]) and saphenous vein (SV). In this study, we investigated the biological differences among IMA-SV, RA-SV, and IMA [....] » Read More

Title: Laser catheter ablation of long-lasting chronic persistent atrial fibrillation (AF)

Graphical abstract: High Density (HD) lasermapping guided AF ablation: gradual abatement of local atrial potential amplitudes (AA1) with abolishment in 4s. This 7th laser impact aimed at the posterior left atrial wall achieved recurrence to sinus rhythm (SR) A2A3 in the 8th se [....] » Read More

Title: Yasser’s electrocardiographic palpitations wave with bilobed apical floating heart syndrome in yasser’s fibrillation-A strange innovative cardiovascular and radiological discoveries-A case report

Atrial fibrillation (AF) is the most common arrhythmia. It is known leading cause of ischemic cerebrovascular accidents. Yasser’s fibrillation (sinusoidal AF) or mixed AF is a new cardiovascular discovery. The partial sino-atrial nodal function has an essential role in the [....] » Read More

Title: Clinical efficacy and mechanistic study of fulvning granules in symptomatic atrial fibrillation: A randomized controlled trial with untargeted metabolomics analysis

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and a major contributor to global morbidity and mortality. Although antiarrhythmic drugs and catheter ablation have advanced AF management, their effectiveness remains limited. Fulvning Granules (FLN), a [....] » Read More

Title: Identification of mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation

Aims: To provide novel insights into the diagnosis of atrial fibrillation (AF), we aimed to identify mitochondria-associated endoplasmic reticulum membranes (MAMs)-related biomarkers for AF.   Methods: A comprehensive analysis was conducted to identify MAM-related biom [....] » Read More

Title: Hybrid RFR-FFR decision-making strategy for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome

Objective: To developed a hybrid resting full-cycle ratio (RFR)- fractional flow reserve (FFR) decision-making approach for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).   Materials and methods: This [....] » Read More